Great Women in Biochemistry
Mildred Cohn (1913-2009) was born in New York to Jewish-Russian immigrants. Her father was a rabbi and Cohn grew up in a religious, Yiddish-speaking home, though one which also prioritized secular education and the arts. Cohn graduated high school by the age of 14 and got her Bachelor’s degree in biochemistry at 18, followed by her Master’s from Columbia University. Unable to afford any further schooling, Cohn got a job researching for the National Advisory Committee for Aeronautics (NACA), which would later become NASA. She was the only woman among seventy men, and was told she shouldn’t expect any promotions. Two years later, she had enough money to return to school, pursuing her PhD at Columbia under recent Nobel Prize-winner Harold Urey. Cohn focused her work on carbon and oxygen isotopes. From there, she moved on to Washington University to do research on metabolism using sulfur isotopes. Later, she switched to using nuclear magnetic resonance and made a huge breakthrough in 1958 when she was able to visualize ATP, the central energy molecule that powers human cells and essentially all living things. Cohn discovered much of what we know about ATP and how it works. All in all, she wrote 160 scientific papers and won numerous awards, including the National Medal of Science (awarded to her by President Reagan). She was the first female editor of the Journal of Biological Chemistry and the first female president of the American Society for Biochemistry and Molecular Biology. In 2009 she was inducted in the National Women’s Hall of Fame. Cohn was married to renowned Jewish physicist Henry Primakoff. Many of her ATP discoveries came while she was working at the lab of another great Jewish scientist, Gerty Cori.
Gerty Theresa Radnitz Cori (1896-1957) was born in Prague. Her father was a chemist who had invented a new way of refining sugar. At 16, Cori decided to become a doctor, but found that she was missing nearly all the prerequisites. So, in one year she took eighteen years-worth of courses in Latin, science, and math. Cori passed her entrance exam and was among the first women ever to be admitted to Prague’s medical school. After graduating, she worked at a children’s hospital and also did research on blood disorders, the thyroid gland, and the body’s ability to regular temperature. Due to persistent food shortages and rising anti-Semitism after World War I, Cori and her husband (also a doctor and scientist) left Prague and moved to New York. The couple did research together at what is now the Roswell Park Cancer Institute in Buffalo, focusing on glucose metabolism. Cori published 11 papers of her own, and another 50 together with her husband. By 1929, the Coris had figured out how the body metabolized glucose in the absence of oxygen, a process now known as the Cori Cycle. For this, they won a Nobel Prize in 1947. This made Cori the first American woman to win a Nobel Prize (and only the third woman overall), as well as the first woman ever to win a Nobel Prize in Medicine. In 1931, the couple took over a lab at Washington University (with Cori being paid one-tenth her husband’s salary). Here they made many more vital scientific discoveries, and mentored a new generation of scientists—six of which went on to win Nobel Prizes of their own. For this reason, their lab was deemed a National Historic Landmark in 2004. Like Mildred Cohn, Gerty Cori won countless awards and was inducted into the National Women’s Hall of Fame. There are craters on the Moon and on Venus named after her, as well as a commemorative US stamp. After battling the disease for a decade, Cori succumbed to bone cancer, likely caused by her extensive work with X-rays.
Words of the Week
In the next world, they will not ask me: “Why were you not Moses?” They will ask me: “Why were you not Zusha?”
– Rabbi Zusha of Anipoli (1718-1800)
Abel “Abba” Kovner (1918-1987) was born in what is today Belarus and grew up in Vilnius (then part of Poland). As a young man, he was a member of HaShomer HaTzair, the Zionist youth movement. When the Nazis invaded Vilnius in 1941, Kovner escaped to a convent, but soon returned to the Vilna Ghetto to organize a Jewish resistance. At the start of 1942, Kovner secretly published a manifesto inside the Ghetto to inspire the Jews to fight back, writing that it was better to die than “go like lambs to the slaughter”. Along with several other young men, Kovner formed the United Partisan Organization, possibly the first armed underground Jewish group in Nazi Europe. Before they could launch their first large-scale attack, the Vilna Ghetto was liquidated in 1943, forcing the group to flee to the surrounding forests. From there, they launched a guerrilla warfare campaign against the Nazis. The small group began calling themselves “the Avengers” (HaNokmim) and were successful enough to draw the attention of the Red Army. They would go on to coordinate with the Soviets to crush the Nazis in Eastern Europe. Once the fate of the Nazis was sealed towards the end of 1944, Kovner was among the founders of a new group, called Bricha (“Escape”), which worked to get Jewish refugees out of Europe and to the Holy Land. Over the next couple of years, they would successfully move 250,000 Holocaust survivors to Israel. Having seen first-hand the horrific devastation inflicted by the Nazis, Kovner yearned for revenge. He started yet another group, called Nakam (“Vengeance”), seeking to punish Germany for the Holocaust. “Plan B” was to poison the water supply in Allied prisoner-of-war camps where Nazi SS soldiers were kept. The far more controversial and shocking “Plan A” was to poison the water supplies of several major German cities in order to kill 6 million Germans, one for each Jew lost in the Holocaust. Thankfully, Plan A was soon abandoned, though Kovner was still arrested by the British and held in a Cairo prison for several months. He did aim to accomplish Plan B, and Nakam members infiltrated a POW camp bakery in April 1946, coating the loaves of bread with arsenic. Over two thousands German soldiers fell ill, though no deaths were reported. In December 1947, Kovner joined the Haganah and fought in Israel’s Independence War as a captain of the Givati Brigade. Following this, he lived out the remainder of his life in a kibbutz, working tirelessly to strengthen the nascent state. He also helped to design several Holocaust museums, and testified at the Eichmann trial. More famously, Kovner wrote a series of poetry books (in Hebrew and Yiddish) describing the struggles he faced during the Holocaust and in Israel’s early years. This made him one of the country’s most celebrated poets and writers. For this, he won the Israeli Prize for Literature in 1970. A heavy smoker, Kovner succumbed to tracheal cancer before his 70th birthday.