“Godfather of THC”
Raphael Mechoulam
Raphael Mechoulam (b. 1930) was born in Bulgaria to a wealthy Sephardic-Jewish family. The family was forced to flee the country due to rampant anti-Semitism, ultimately surviving the Holocaust and settling in Israel in 1949. During his IDF service, Mechoulam worked as a chemical engineer and helped to develop insecticides. Falling in love with scientific research, he continued to study chemistry after his military service, earned his Master’s from the Hebrew University, then his PhD from the Weizmann Institute. After studies at the Rockefeller Institute in New York, Mechoulam returned to Israel to teach at both of his former universities. His primary field of research is cannabis. In fact, it was Mechoulam who first discovered, isolated, and synthesized THC, the primary active ingredient in cannabis. He would later discover and synthesize other important cannabinoids (a term he coined). Mechoulam was one of the pioneers of medicinal cannabis, and has said that medicinal cannabis could probably replace “ten to twenty percent of all pharmaceuticals”. More recently, he discovered endocannabinoids—molecules similar to THC that are naturally produced by the body, playing a key role in immunity and in regulating human emotions. All in all, Mechoulam published over 350 scientific papers. In 2016, he received a lifetime achievement award at Harvard’s School of Medicine. He was also the subject of an eye-opening documentary called The Scientist. Now a nonagenarian, Mechoulam continues to do research at his Jerusalem lab.
Words of the Week
Jewish time sees us as travellers on the road to a destination not yet reached; wayfarers on a journey begun by our ancestors, to be continued by our children.
Mildred Cohn (1913-2009) was born in New York to Jewish-Russian immigrants. Her father was a rabbi and Cohn grew up in a religious, Yiddish-speaking home, though one which also prioritized secular education and the arts. Cohn graduated high school by the age of 14 and got her Bachelor’s degree in biochemistry at 18, followed by her Master’s from Columbia University. Unable to afford any further schooling, Cohn got a job researching for the National Advisory Committee for Aeronautics (NACA), which would later become NASA. She was the only woman among seventy men, and was told she shouldn’t expect any promotions. Two years later, she had enough money to return to school, pursuing her PhD at Columbia under recent Nobel Prize-winner Harold Urey. Cohn focused her work on carbon and oxygen isotopes. From there, she moved on to Washington University to do research on metabolism using sulfur isotopes. Later, she switched to using nuclear magnetic resonance and made a huge breakthrough in 1958 when she was able to visualize ATP, the central energy molecule that powers human cells and essentially all living things. Cohn discovered much of what we know about ATP and how it works. All in all, she wrote 160 scientific papers and won numerous awards, including the National Medal of Science (awarded to her by President Reagan). She was the first female editor of the Journal of Biological Chemistry and the first female president of the American Society for Biochemistry and Molecular Biology. In 2009 she was inducted in the National Women’s Hall of Fame. Cohn was married to renowned Jewish physicist Henry Primakoff. Many of her ATP discoveries came while she was working at the lab of another great Jewish scientist, Gerty Cori.
Gerty Theresa Radnitz Cori (1896-1957) was born in Prague. Her father was a chemist who had invented a new way of refining sugar. At 16, Cori decided to become a doctor, but found that she was missing nearly all the prerequisites. So, in one year she took eighteen years-worth of courses in Latin, science, and math. Cori passed her entrance exam and was among the first women ever to be admitted to Prague’s medical school. After graduating, she worked at a children’s hospital and also did research on blood disorders, the thyroid gland, and the body’s ability to regular temperature. Due to persistent food shortages and rising anti-Semitism after World War I, Cori and her husband (also a doctor and scientist) left Prague and moved to New York. The couple did research together at what is now the Roswell Park Cancer Institute in Buffalo, focusing on glucose metabolism. Cori published 11 papers of her own, and another 50 together with her husband. By 1929, the Coris had figured out how the body metabolized glucose in the absence of oxygen, a process now known as the Cori Cycle. For this, they won a Nobel Prize in 1947. This made Cori the first American woman to win a Nobel Prize (and only the third woman overall), as well as the first woman ever to win a Nobel Prize in Medicine. In 1931, the couple took over a lab at Washington University (with Cori being paid one-tenth her husband’s salary). Here they made many more vital scientific discoveries, and mentored a new generation of scientists—six of which went on to win Nobel Prizes of their own. For this reason, their lab was deemed a National Historic Landmark in 2004. Like Mildred Cohn, Gerty Cori won countless awards and was inducted into the National Women’s Hall of Fame. There are craters on the Moon and on Venus named after her, as well as a commemorative US stamp. After battling the disease for a decade, Cori succumbed to bone cancer, likely caused by her extensive work with X-rays.